Laboratory for Photonics and Nanostructures
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Nanotechnology and Microfluidic Devices
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Puce Presentation

Nanoflu group's research aims at understanding biophysical phenomena within microfluidic devices, as well as at promoting new nanofabrication technologies for the life sciences.

Our research is focused on the five following topics:

MicroFlu On-chip separation of biomolecules (Bioanalysis)
Anne-Marie Haghiri-Gosnet
We develop high-efficiency protein separation methods based on the perfect control of the surface charge. You'll find more information at the DIMIPOLE project's webpage.
DynaNets Microsystems to investigate the dynamics of reactive networks (DynaNets)
Charlie Gosse
From protocol conception to practical on-chip implementation, at the molecule or at the organism scale.
NOMAD Developement of micro- and nanoswimmers (Nomad)
Gilgueng Hwang
We develop strategies to control the movement of micro- and nano-metric swimmers for the detection and manipulation of biochemical targets.
ArtNets Artificial reaction networks (ArtNets)
André Estévéz-Torres and Jean-Christophe Galas
We engineer chemical reaction networks using DNA biochemistry. Our goal is to mimick in vitro the complex spatiotemporal behaviors observed in biology. You'll find more information at the ArtNets project's webpage.
OptoFlu Nanophotonics and Optofluidics (OptoFlu)
Anne-Marie Haghiri-Gosnet
Fabrication and study of optical biosensors integrated in fluidic devices for a sensitive detection under flow (metallic plasmonic nanostructures and liquid microcavities).

We also develop new micro- and nano-fabrication processes for microfluidics and optics:

AlterNano Innovative micro- and nano-fabrication methods for fluidic devices (AlterNano)
Anne-Marie Haghiri-Gosnet and Dominique Decanini
Large surface nanopatterning in biomaterials (soft UV nanoimprint with flexible stamp, capillary-guided self assembling of nanoparticles). Integration of nano/microstructures in fluidic devices with specific bonding processes.

Our research involves using a wide range of instrumentation in microscopy, microfluidics, electronics, and biochemistry

nanoflu_facilities Experimental facilities and instrumentation

You'll find here a list of our exprimental capabilities
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Puce Members

Group leader

 Haghiri-Gosnet Anne-Marie  (+33) 1 69 63 61 22  

Full-time staff

 Pallandre Antoine  (+33) 1 69 63 60 09  
 Cattoni Andrea  (+33) 1 69 63 60 48  
 Decanini Dominique  (+33) 1 69 63 61 20  
 Estevez-Torres Andre  (+33) 1 69 63 61 61  
 Galas Jean-Christophe  (+33) 1 69 63 63 57  
 Gosse Charlie  (+33) 1 69 63 61 55  
 Hwang Gilgueng  (+33) 1 69 63 61 35  

Trainees, PhDs, post-docs, guests

 Zadorin Anton  (+33) 1 69 63 61 19  
 Delapierre François-damien  (+33) 1 69 63 60 85  
 Lee Tin Wah Jonathan  (+33) 1 69 63 61 19  
 Grosso David  (+33) 1 69 63 61 66  
 Ceratti Davide  (+33) 1 69 63 61 66  
 Alvo Sebastien  (+33) 1 69 63 61 19  
 Araki Ayako  (+33) 1 69 63 60 89  
 Barbot Antoine  (+33) 1 69 63 60 60  
 Zambrano Adrian  (+33) 1 69 63 61 19  
 Roy Emmanuel  (+33) 1 69 63 61 06  
 Castro Arias Juan Manuel  (+33) 1 69 63 63 53  
 Zhao Xuan  (+33) 1 69 63 60 04  
 Nadal Emmanuelle  (+33) 1 69 63 60 41  
 Dalstein Olivier  (+33) 1 69 63 61 66  

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Puce Patents

  • Centrifugal microfluidic system for nucleic acid sample preparation, amplification and detection, M. Bergeron, E. Roy, M Boissinot, T. Veres, R. Peytavi, M Madou, United States 8,303,911, (2012-12-06)
  • Valveless centrifugal microfluidic platform and method for performing biological assays therein , M Mounier, E. Roy, L Clime, T. Veres, US provisional application 61/504,273, (2012-03-22)
  • Procédé de détermination du mécanisme réactionnel d'une réaction et dispositif associé, C. Gosse, A. Lemarchand, L. Jullien, T. Le Saux, K. Zrelli, FR 1161290, (2011-12-07)
  • 3D Microfluidic Device with Open-Through TPE , E. Roy, D Brassard, WO International application 2012109724 A1, (2011-02-15)
  • procede de fabrication d'une puce microfluidique, puce et plaque associees, C. Nanteuil, A.-M. Haghiri-Gosnet, FR 1054183, (2010-05-28)
  • Puce microfluidique, support, systeme et procede de mise en oeuvre pour une regulation thermique spatialement controlee et rapide d??un echantillon, G. Velve Casquillas, M. Le Berre, A. Plecis, Y. Chen, FR 1001905, (2010-05-04)
  • Semipermanently closed microfluidic valve, E. Roy, T Veres, J.-C. Galas, WO International application 201134038 A1, (2010-04-26)
  • Microfluidic device, composition and method of forming, E. Roy, US 20110085949 A1, (2009-10-08)
  • Dispositif pour manipuler et/ou mesurer des forces sur des molécules, des organelles, des cellules ou tout objet de taille comparable, C. Gosse, V. Croquette, FR 9908903, (1999-07-07)
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Puce Recent publications

Publication in journals
  • Electrochemiluminescence on-a-chip: Towards a hand-held electrically powered optofluidic source , S. Meance, J. Gamby, M. Faure, Q. Kou, A.-M. Haghiri-Gosnet, 129, 150 (2014)
  • From cellular lysis to microarray detection, an integrated thermoplastic elastomer (TPE) point of care Lab on a Disc , E. Roy, M. Bergeron, M Madou, M Boissinot, L Clime, R. Peytavi, L Malic, M Mounier, G Stewart, T. Veres, Lab Chip , (2014)
  • Very Toxic E. Coli colorimetric detection on centripetal microfluidic blade , E. Roy, X Hoa, M. Geissler, B Burton, T. Veres, Lab Chip , (2014)
  • Peptidic ligands to control the three-dimensional self-assembly of quantum rods in aqueous media[PDF] , T. Bizien, P. Even-Hernandez, M. Postic, E. Mazari, S. Chevance, A. Bondon, C. Hamon, D. Troadec, L. Largeau, C. Dupuis, C. Gosse, F. Artzner, V. Marchi, Small 10, 3707 (2014)
  • Improved electrochemical detection of a transthyretin synthetic peptide in the nanomolar range with a two-electrode system integrated in a glass/PDMS microchip , M. Faure, A. Pallandre, S. Chebil, I. Le Potier, M. Taverna , B. Tribollet, C. Deslouis, A.-M. Haghiri-Gosnet, J. Gamby, Lab Chip 14, 2800 (2014)
  • A microdevice to locally electroporate embryos with high efficiency and reduced cell damage[PDF] , E. Mazari, X. Zhao, I. Migeotte, J. Collignon, C. Gosse, A. Perea-Gomez, Development 141, 2349 (2014)
  • Modeling and Swimming Property Characterizations of Scaled-Up Helical Microswimmers , T. Xu, G. Hwang, N. Andreff, S. Regnier, 19, 1069 (2014)
  • A microdevice for parallelized pulmonary permeability studies , L. Bol, J.-C. Galas, H. Hillaireau, I. Le Potier, V. Nicolas, A.-M. Haghiri-Gosnet, E. Fattal, M. Taverna , 16, 277 (2014)
  • Investigating of labelling and detection of transthyretin synthetic peptide derivatized with naphthalene-2,3-dicarboxaldehyde , M. Faure, S. korchane, I. Le Potier, A. Pallandre, C. Deslouis, A.-M. Haghiri-Gosnet, J. Gamby, 116, 8 (2013)
  • Magnetic control of protein spatial patterning to direct microtubule self-assembly[PDF] , C. Hoffmann, E. Mazari, C. Gosse, L. Bonnennay, S. Hostachy, J. Gautier, Z. Gueroui, ACS Nano 7, 9647 (2013)
  • Electrochemical detection of single microbeads manipulated by optical tweezers in the vicinity of ultramicroelectrodes[PDF] , E. Suraniti, F. Kanoufi, C. Gosse, X. Zhao, R. Dimova, B. Pouligny, N. Sojic, Anal. Chem. 85, 8902 (2013)
  • Pressure-assisted selective preconcentration in a straight nanochannel[PDF] , A.-C. Louer, A. Plecis, A. Pallandre, J.-C. Galas, A. Estevez-Torres, A.-M. Haghiri-Gosnet, Anal. Chem. 85, 7948 (2013)
  • High-throughput observation of compartmentalized biochemical oscillators , K. Hasatani, M. Leocmach, A. Genot, A. Estevez-Torres, T. Fujii, Y. Rondelez, Chem. Commun. , (2013)
  • Identification of two-step chemical mechanisms and determination of thermokinetic parameters using frequency responses to small temperature oscillations[PDF] , F. Closa, C. Gosse, L. Jullien, A. Lemarchand, J. Chem. Phys. 138, 244109 (2013)
  • Swimming Property Characterizations of Magnetic Polarizable microrobots , H. Salmon, L. Couraud, G. Hwang, , 5520 (2013)
  • Spatial Waves in Synthetic Biochemical Networks[PDF] , A. Padirac, T. Fujii, A. Estevez-Torres, Y. Rondelez, J. Am. Chem. Soc. 135, 14586 (2013)
  • Computational study of velocity profile obtained in microfluidic channel bearing a fluidic transistor: Toward highly resolved electrophoretic separation [PDF] , I. Charhrouchni, A. Pallandre, I. Le Potier, C. Deslouis, A.-M. Haghiri-Gosnet, Electrophoresis 34, 725 (2013)
  • A nanoliter-scale open chemical reactor [PDF] , J.-C. Galas, A.-M. Haghiri-Gosnet, A. Estevez-Torres, Lab Chip 13, 415 (2013)
  • Spatiotemporal control of microtubule nucleation and assembly using magnetic nanoparticles[PDF] , C. Hoffmann, E. Mazari, S. Lallet, R. Le Borgne, V. Marchi, C. Gosse, Z. Gueroui, Nature Nanotech. 8, 199 (2013)
  • Note: Helical nanobelt force sensors , G. Hwang, H. Hashimoto, Rev. Sci. Instr. 83, 126102 (2012)
  • Self-assembled titanium calcium oxide nanopatterns as versatile reactive nanomasks for dry etching lithographic transfer with high selectivity [PDF] , M. Faustini, G.L. Drisko, A.A. Letailleur, R. Salas Montiel, C. Boissiere, A. Cattoni, A.-M. Haghiri-Gosnet, G. Lerondel, Nanosc. advanced article 2013, (2012)
  • Single particle demultiplexer based on domain wall conduits [PDF] , A. Torti, V. Mondiali, A. Cattoni, M. Donolato, E. Albisetti, A.-M. Haghiri-Gosnet, P. Vavassori, R. Bertacco, Appl. Phys. Lett. 101, 142405 (2012)
  • Tuning silica particle shape at fluid interfaces[PDF] , A. Fang, C. Gosse, C. Gaillard, X. Zhao, J. Davy, Lab Chip 12, 4960 (2012)
  • Chemical mechanism identification from frequency response to small temperature modulation[PDF] , A. Lemarchand, H. Berthoumieux, L. Jullien, C. Gosse, J. Phys. Chem. A 116, 8455 (2012)
  • Extremely thin planarized grating for sub-diffraction (<100nm) far-field imaging of living cell membranes [PDF] , A. Cattoni, A. Talneau, A.-M. Haghiri-Gosnet, J.-C. Girard, A. Sentenac, Microelectron. Eng. 97, 154 (2012)
  • Three-dimensional self-assembling of gold nanorods with controlled macroscopic shape and local smectic B order[PDF] , C. Hamon, M. Postic, E. Mazari, T. Bizien, C. Dupuis, P. Even-Hernandez, A. Jimenez, L. Courbin, C. Gosse, F. Artzner, V. Marchi-Artzner, ACS Nano 6, 4137 (2012)
  • Concentration landscape generators for shear free dynamic chemical stimulation , M. Morel, J.-C. Galas, M. Dahan, V. Studer, Lab Chip , (2012)
Publications in books
  • Coherent spontaneous emission of light due to surface waves source , J.-J. Greffet, R. Carminati, K. Joulain, J. P. Mulet, C. Henkel, S. Mainguy, Y. Chen, Optical nanotechnologies: The manipulation of surface and local plasmons 88, 163 (2000)
All publications
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